Behçet’s disease (BD) is a form of vasculitis that manifests with orogenital ulcers, uveitis, skin inflammation, arthritis, enterocolitis and inflammation in other organs.
Despite a worldwide distribution, BD clusters in an area that extends from far Eastern Asia to the Mediterranean basin and is relatively common in Turkey and Japan.
Several lines of evidence suggest that host genetic factors play a pivotal role in determining susceptibility to BD. In particular, it has long been known that BD is associated with the major histocompatibility complex HLA–B5 allele and, more specifically, with HLA–B*51, the predominant split of the HLA–B5 broad antigen. HLA-B*51 is, therefore, the most strongly associated risk factor for Behçet’s disease, which has been confirmed in multiple populations.
GENVINSET® HLA BEHÇET’S DISEASE is a kit for the determination of the HLA-B*51/52 group of alleles, by Real Time PCR using TaqMan® probes technology.