In most human beings, the ability to digest lactose rapidly decreases after the breastfeeding period (primary lactose intolerance). This is due to a reduction in the lactase-phlorizin hydrolase enzyme (LPH), which is responsible for the hydrolysis of lactose to glucose and galactose, sugars which are both easily absorbed in the intestine. However, some individuals maintain the ability to digest lactose as adults.
The frequency of persistence of lactase activity is high in north-European populations (>90% in Sweden and Denmark), whereas it progressively decreases towards the south of Europe and the Middle East (around 50% in France, Spain and some Arabic populations), and is very low in Asian and African populations, although it is common in pastoralist populations (around 1% in China, 5-20% in East Africa).
Lactose intolerance causes several symptoms that include abdominal pain, bloating, diarrhoea and gas as the most common, and other wide ranging symptoms such as nausea, headache, lack of concentration, severe fatigue, muscular and joint pains, etc.
Genvinset® Lactose Intolerance is a kit for the determination of the polymorphisms C13910T and G22018A of the MCM6 gene by Real Time PCR using specific TaqMan® probes technology.