Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Although MTHFR protein does not participate in the clotting cascade as other proteins such as FII and FV (and therefore belonging to the well-known group of coagulation factors), the involvement of MTHFR in the folate metabolic pathway may affect thrombophilia development, as well as increased cancer risk or Alzheimer’s disease appearance.
MTHFR gen can present different polymorphisms. The most common and studied variant is the MTHFR C677T polymorphism but, also, the MTHFR A1298C mutation has been studied. The frequency of both MTHFR polymorphisms differs among the different ethnicities.
Genvinset® MTHFR A1298C is a semi-automated kit for the in vitro qualitative detection of the A1298C polymorphism (NCBI dbSNP rs1801131; NM_001330358.2:c.1409A>C) in the Methylene tetrahydrofolate reductase (MTHFR) gene (OMIM: 607093) associated with thrombophilia risk in genomic DNA extracted from whole blood using Real Time PCR technology with specific TaqMan® probes.
Patients who can benefit from this determination are those referred by a specialist. The results of this test should not be the only ones on which the therapeutic decision is based and should be used as an aid in the diagnosis together with results of other markers of the disease.
The intended user of the kit is technical personnel trained to carry out the protocol and the interpretation of results described in the instructions for use.
Genvinset® MTHFR A1298C is a kit for the in vitro qualitative detection of the A1298C polymorphism (NCBI dbSNP rs1801131; NM_001330358.2:c.1409A>C) in the Methylene tetrahydrofolate reductase (MTHFR) gene (OMIM: 607093) associated with thrombophilia risk in genomic DNA extracted from whole blood using Real Time PCR technology with specific TaqMan® probes.
Patients who can benefit from this determination are those referred by a specialist. The results of this test should not be the only ones on which the therapeutic decision is based and should be used as an aid in the diagnosis together with results of other markers of the disease.
The intended user of the kit is technical personnel trained to carry out the protocol and the interpretation of results described in this document.
Log in to see the product files.
BDR
CE-IVD
Company
Products
We use cookies to give you the best experience on our website. You can learn more about which cookies we use or disable them in the settings.
Read moreSettings Reject AcceptEste sitio web utiliza cookies para mejorar su experiencia mientras navega por el sitio web. De estas, las cookies que se clasifican como necesarias se almacenan en su navegador, ya que son esenciales para el funcionamiento de las funcionalidades básicas del sitio web. También utilizamos cookies de terceros que nos ayudan a analizar y comprender cómo utiliza este sitio web. Estas cookies se almacenarán en su navegador solo con su consentimiento. También tiene la opción de optar por no recibir estas cookies. Pero la exclusión voluntaria de algunas de estas cookies puede afectar su experiencia de navegación.
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-analitica | 1 year | The cookie is set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the category "Analytics". |
cookielawinfo-checkbox-funcional | 1 year | Set by the GDPR Cookie Consent plugin to store the user consent for cookies in the category "Functional". |
cookielawinfo-checkbox-necesaria | 1 year | Set by the GDPR Cookie Consent plugin to store the user consent for cookies in the category "Necessary". |
cookielawinfo-checkbox-rendimiento | 1 year | Set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the "Performance" category . |
CookieLawInfoConsent | 1 year | Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie. |
elementor | never | This cookie is used by the website's WordPress theme. It allows the website owner to implement or change the website's content in real-time. |
PHPSESSID | session | This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed. |
Cookie | Duration | Description |
---|---|---|
_ga | 2 years | The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors. |
_ga_TYDMHR1L0J | 2 years | This cookie is installed by Google Analytics. |
_gat_gtag_UA_82282813_1 | 1 minute | Set by Google to distinguish users. |
_gid | 1 day | Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously. |
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-otra | 1 year | No description |
cookielawinfo-checkbox-publicitaria | 1 year | No description |
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-analitica | 1 year | The cookie is set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the category "Analytics". |
cookielawinfo-checkbox-funcional | 1 year | Set by the GDPR Cookie Consent plugin to store the user consent for cookies in the category "Functional". |
cookielawinfo-checkbox-necesaria | 1 year | Set by the GDPR Cookie Consent plugin to store the user consent for cookies in the category "Necessary". |
cookielawinfo-checkbox-rendimiento | 1 year | Set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the "Performance" category . |
CookieLawInfoConsent | 1 year | Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie. |
elementor | never | This cookie is used by the website's WordPress theme. It allows the website owner to implement or change the website's content in real-time. |
PHPSESSID | session | This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed. |
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-otra | 1 year | No description |
cookielawinfo-checkbox-publicitaria | 1 year | No description |
Cookie | Duration | Description |
---|---|---|
_ga | 2 years | The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors. |
_ga_TYDMHR1L0J | 2 years | This cookie is installed by Google Analytics. |
_gat_gtag_UA_82282813_1 | 1 minute | Set by Google to distinguish users. |
_gid | 1 day | Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously. |